TABLE 1.

Induction of ISGs in Huh7 cells by IFN-α and in HCV-infected human and chimpanzee livers

ISGGenBank accession no.Reference(s) reporting induction by:Effect on HCV in 293 cellsa
IFN-α in Huh7 cellsHCV-infected livers
ISG56001548 32, 39, 45, 49, 53 5, 6, 33, 39, 58, 61
GBP1 002053 32, 39, 45 6, 35, 58
ISG9-27 003641 32, 45, 49, 53 6, 35, 61
1-8D 006435 53 6
1-8U 021034 53
MTAP44D28915 32, 53 5, 6, 33
ADAR1 001111 6, 35, 39
ISG20 002201 39, 45 6, 39+
Viperin AF442151 33, 39, 49 6, 33, 61+
PKR AH008429 32, 45, 53+
ISG15 005101 32, 39, 45 5, 6, 33, 39, 58, 61
OAS1 016816 32, 39, 45 5, 6, 33, 39, 61
OAS1 002534 32, 39, 45, 53 5, 6, 39, 61
OAS-L 003733 32, 39, 45 6, 35, 61
OAS-L 198213 32, 39, 45 6, 35, 61
PLSCR1 021105 39, 45, 53 6, 39
MAPK8 002750 32
SAMHD1015474 32 33, 39
IFI44 006417 39, 45, 49 6, 61
IFI44L 006820 39 39
UBE2L6 004223 32, 45 6, 39, 61
USP18 017414 32, 39, 45 6, 39
BST2 004335 45, 53 35
FLJ20637 AK000644 53 6, 61
FLJ38348 AK095667 53 6
STAF50 X82200 39, 45 5, 6, 33, 39, 58
ISG12 BN000227 39 6, 39
FLJ20035 AK000042 45 6
C1ORF9 DQ053381 45
  • a + indicates the ISG inhibits the replication of HCV replicons.