TABLE 2.

Comparison of the effects of select mutations in gp120JR-CSF on the binding of MAbs 2G12 and IgG1 b12

MutationaAffinity of antibody for indicated mutant relative to wild type (%)
2G12IgG1 b12
N295A280
N295Q4261
N332A375
N339A830
N339Q91567
N386A2123
N392A44
N392Q6142
S334T106
L416A22
F353A1529
K421A1918
K404A32101
S406A3360
T408A4096
S365A1,173667
G458A349857
  • a Amino acid numbering is based on the HxB2 sequence.