TABLE 1.

Variability of N-linked sites identified by substitutional mutagenesis as being part of the 2G12 epitope

N-linked siteGlycan typeaVariability (%)
Clade AClade BClade CTotal
295Mannose40158031
332Mannose25141315
386Mannose15151515
392Mannose5111611
397Complex45263731
448Mannose54106
  • a Mannose refers to either high-mannose or hybrid glycans.