TABLE 4.

Novel epitopes detected by comprehensive Elispot analysis

HCV proteinaa positionSequenceaHLA restric- tionSub- ject(s)
E2610-618DYPYRLWHYCw7P4
P7781-800KWVPGAVYTFYGMWP     LLLLL*NDP9, P11, P14
NS31171-1190CPAGHAVGIFRAAVCTRGVA*NDP9
NS31435-1443ATDAL MTGYA1P2
NS5A2191-2210ARGSPPSVASSSASQLSAPS*NDP12
NS5B2568-2577QPEKGGRKPAB55P7
NS5B2898-2907SPGEINRVAAB55P7
  • a *, Minimal epitope and HLA restriction not determined.