TABLE 5.

Inheritance of Mamu-B*17, -DRB1*1003, and -DRB1*0306 alleles

AnimalaPresence of allelebLinkagecECd
Mamu-B*17Mamu-DRB1*1003Mamu-DRB1*0306
98016+++NY
99006+++NY
00026+++NN
95071+++YY
95061+++YY
98017+++YN
96112+++YY
96072+++YN
99026+++YN
  • a Animals were infected with SIVmac239 and were part of the 196 SIV-infected cohort except for animals 99006 and 00026. These two animals were infected with different strains of SIV. Animal 99006 was infected with a variant of SIVmac239 that had three immunodominant epitopes mutated (14). Animal 00026 was infected with SIVmac251 (the clone SIVmac239 was derived subsequently from this strain).

  • b All animals were typed for the alleles Mamu-B*17, -DRB1*1003, and -DRB1*0306 using sequence-specific PCR, and results were confirmed with microsatellites. These alleles were also typed in animals 98016, 95071, and 95061 using cDNA libraries.

  • c Linkage indicates whether Mamu-B*17 was in the same chromosome with Mamu-DRB1*1003 and -DRB1*0306. Y, yes; N, no.

  • d Y, yes; N, no.