TABLE 1.

Clinical pathology

Parameter and time relative to vector administrationaResults for individual animals
ControlNaive 1Naive 2Preimmunized 1Preimmunized 2
Aspartate aminotransferase concn (IU/liter)
    Pre1829241838
    Post686,5401,360187402
Alanine aminotransferase concn (IU/liter)
    Pre1651283746
    Post571,855517130136
Gamma glutamyl transpeptidase concn (IU/liter)
    Pre61791068581
    Post5557812513799
Hemoglobin concn (g/dl)
    Pre12.913.713.213.613.5
    Post12.611.96.911.6NDb
Platelet count (105/mm3)
    Pre4.23.75.642.9
    Post31.41.61.6ND
White blood cell count (103/mm3)
    Pre9.913.66.515.48.8
    Post139.24.215.4ND
Prothrombin time (s)
    Pre131313.710.613.9
    Post12.916.6181314.6
Partial thromboplastin time (s)
    Pre25.228.721.222.223.7
    Post26.242.536.425.330
Fibrin split product concn (mg/ml)
    Pre<2.5<2.5<2.52010
    Post208040160160
  • a Pre, 1 day prior to vector administration; Post, 24 h after vector administration.\

  • b ND, not determined due to the blood clot.