TABLE 2.

Comparison of microarray experiments with IRF-3 5D-expressing cells, virus-infected cells, or IFN-stimulated cellsa

GeneUpregulation (+) or downregulation (−) with:
IRF-3 5DHSV-1bHCMVcHPV31dIFNe
αβ
ISG54+++++
ISG56+++++
ISG60+ND+NDNDND
CIG5+++ND+ND
PMA-induced protein 1+++ND++
Microtubular aggregate protein 44<2NDND++
2′-5′ OAS<2++++
ISG15<2++ND++
GBP1<2ND+++
  • a Upregulated genes (+) and downregulated genes (−) are indicated. Genes found to be upregulated by <2-fold (<2) are also reported. ND, no data.

  • b As determined previously (27, 41).

  • c As determined previously (5, 51).

  • d As determined previously (6).

  • e As determined previously (8, 9, 27).