TABLE 6.

Comparison of sequence lengths and PNLG between HIV-1 subtypes B and C gp120

Genomic regionAnalysis groupaSequence length interquartileGlycan no. interquartileComparisonP value
Sequence length comparisonbGlycan no. comparisonb
gp120B-ref509-51926-28B-ref/C-ref0.010.01
C-ref492-50924-26B-db/C-db8.44 × 10−150.004
B-db507-51524-27B-ref/B-db0.440.02
C-db499-51023-26C-ref/C-db0.450.86
V1B-ref25-314-5B-ref/C-ref0.030.06
C-ref17-273-4B-db/C-db3.37 × 10−130.0008
B-db26-324-5B-ref/B-db0.750.43
C-db22-283-5C-ref/C-db0.310.45
V2B-ref40-464-5B-ref/C-ref0.520.85
C-ref42-454-5B-db/C-db3.33 × 10−50.50
B-db40-444-5B-ref/B-db0.230.52
C-db41-454-5C-ref/C-db0.160.88
V3B-ref35-353-3B-ref/C-ref0.360.0036
C-ref35-351-2B-db/C-db0.02<2.2 × 10−16
B-db35-352-3B-ref/B-db0.610.4259
C-db35-352-2C-ref/C-db0.600.7318
V4B-ref31-334-5B-ref/C-ref0.0050.02
C-ref23-303-4B-db/C-db1.74 × 10−120.02
B-db30-334-5B-ref/B-db0.500.75
C-db27-314-5C-ref/C-db0.060.01
V5B-ref9-102-2B-ref/C-ref0.570.09
C-ref9-111-2B-db/C-db0.130.004
B-db9-111-2B-ref/B-db0.260.12
C-db9-111-2C-ref/C-db0.830.71
  • a B-ref, 12 selected sequences from the subtype B panel of reference strains; B-db, 176 well-characterized subtype B database sequences; C-ref, 12 selected sequences from the C panel of reference strains; C-db, 122 well-characterized subtype C database sequences.

  • b Bolded P values (P < 0.002) are significant differences after Bonferroni correction. Underlined P values (0.002 < P < 0.05) are significantly different trends after Bonferroni correction.