TABLE 1.

Analysis of residual decay in LTR circles

Expt. no.ParameterPhosphorimager resultsResidual decay resultsc
t1/2 (h)95% CIPbt1/2 (h)95% CI
1dCells−1a33.9730.00-39.16
2-LTR circles35.4032.15-39.370.510NANA - 367.45
Total HIV49.4541.01-62.260.005
2dCells−129.9023.63-40.71
2-LTR circles26.1224.31-28.220.025206.531225.37 - 112.77
1-LTR circles27.5022.11-36.380.590342.69NA - 64.66
3eCells−127.7425.66-30.19
2-LTR circles28.3026.13-30.850.691NANA - 291.47
1-LTR circles23.8820.56-28.480.185171.46NA - 64.99
Total HIV21.0218.07-25.130.042
  • a Cells−1, doubling time of the cells.

  • b P values are for comparison of t1/2 and cells−1.

  • c Residual decay relative to cell division. NA, not available.

  • d Experiment with replication-competent virus.

  • e Experiment with integrase mutant virus.