TABLE 2.

Comparison of the magnitude of HIV-1-specific immune responses with markers of disease progressiona

ProteinAbsolute CD4+ T cells vRNA in plasma
Rb (95% CI)Pr (95% CI)P
p240.29 (−0.11, 0.61)0.1537 −0.44 (−0.71, −0.06) 0.0244
gp1600.07 (0.46 to 0.34)0.73760.34 (−0.08, 0.65)0.1066
20-mer peptide pools
    Total 0.46 (0.11, 0.71) 0.0135 −0.50 (−0.74, −0.15) 0.0069
    Gag 0.54 (0.20, 0.76) 0.0033 −0.60 (−0.79, −0.29) 0.0008
        p17 0.50 (0.16, 0.74) 0.0065 −0.14 (−0.49, 0.25)0.4853
        p24 0.39 (0.03, 0.67) 0.0376 −0.52 (−0.75, −0.18) 0.0047
        NC0.27 (−0.12, 0.58)0.1697−0.36 (−0.65, 0.02)0.0605
    Pol 0.45 (0.09, 0.70) 0.0163 −0.23 (−0.56, 0.15)0.2359
        Pr0.09 (−0.29, 0.45)0.6555−0.17 (−0.51, 0.22)0.3983
        RT0.24 (−0.15, 0.56)0.21730.03 (−0.34, 0.40)0.8644
        RNase H0.04 (−0.33, 0.41)0.8219−0.05 (−0.42, 0.33)0.7927
        IN 0.49 (0.15, 0.73) 0.0078 −0.36 (−0.65, 0.01)0.0588
    Env−0.03 (−0.40, 0.35)0.8911−0.26 (−0.58, 0.13)0.1828
        gp120−0.08 (−0.44, 0.30)0.6690−0.04 (−0.41, 0.34)0.8364
        gp410.14 (−0.25, 0.49)0.4864−0.17 (−0.51, 0.21)0.3803
    Nef0.00 (−0.37, 0.38)0.98790.04 (−0.34, 0.41)0.8442
  • a The magnitude of responses was defined as the sum total of IFN-γ responses (SFU/106 PBMC) minus the medium background.

  • b R, Spearman rank correlation coefficient. CI, confidence interval. Statistically significant values are represented in boldface type.