TABLE 3.

Comparison of the breadth of HIV-1-specific responses with markers of disease progressiona

ProteinAbsolute CD4 count Viral load in plasma
Rb (95% CI)Pr (95% CI)P
Total 0.62 (0.32, 0.81) 0.0004 −0.38 (−0.66, −0.01) 0.0474
Gag 0.53 (0.02, 0.76) 0.0034 −0.43 (−0.69, −0.07) 0.0230
Pol 0.38 (0.01, 0.66) 0.0433 −0.32 (−0.2, 0.06)0.0998
Env0.13 (−0.25, 0.48)0.5064−0.24 (−0.56, 0.15)0.2253
Nef−0.03 (−0.40, 0.35)0.89260.18 (−0.20, 0.52)0.3515
  • a Breadth was defined as the number of peptide pools (10 peptides per pool) for which positive ELISPOT responses were observed. An ELISPOT response was considered positive if ≥50 SFU/106 PBMC and ≥3 times the value for the subject's medium control.

  • b Spearman rank correlation coefficient. CI, confidence interval. Statistically significant values are represented in boldface type.