TABLE 3.

Phenotypic sensitivity of mutant virus strains to CV-N and other entry inhibitors

Entry inhibitorEC50 (μM) for:
HIV-1(IIIB) (WT)aHIV-1(NL-4.3) (WT)CV-N concn (μg/ml) (selection series, code no.) (HIV-1 strain)
1 (1, 113-24) (IIIB)1 (2, 108-4) (IIIB)2 (2a, 113-14) (IIIB)2 (2b, 113-15) (IIIB)1.5 (3, 113-23) (NL-4.3)
CV-N0.002 ± 0.0010.0007 ± 0.00050.005 ± 0.0030.016 ± 0.0030.040 ± 0.0210.039 ± 0.0230.005 ± 0.0
GNA0.005 ± 0.0010.011 ± 0.0090.017 ± 0.010.140 ± 0.0300.116 ± 0.1200.076 ± 0.0640.018 ± 0.028
HHA0.004 ± 0.0020.013 ± 0.0040.020 ± 0.0050.130 ± 0.0150.068 ± 0.0180.042 ± 0.0170.056 ± 0.036
LOA0.003 ± 0.0010.014 ± 0.0030.071 ± 0.0280.031 ± 0.00.030 ± 0.026
UDA0.138 ± 0.0410.053 ± 0.0040.213 ± 0.0560.287 ± 0.1720.115 ± 0.00.218 ± 0.0160.138 ± 0.056
CA0.021 ± 0.0210.082 ± 0.0440.400 ± 0.00.220 ± 0.0840.320 ± 0.1120.160 ± 0.112
2G12b1.1 ± 0.12>50>50>50>50
T-20b0.031 ± 0.0170.015 ± 0.00.0092 ± 0.0040.045 ± 0.0070.012 ± 0.0050.011 ± 0.000.0060 ± 0.0028
DS 5000b0.33 ± 0.120.25 ± 0.070.3 ± 0.01.4 ± 0.211.3 ± 0.351.3 ± 0.351.35 ± 0.21
AMD3100b0.05 ± 0.030.0072 ± 0.00110.021 ± 0.0160.070 ± 0.0280.06 ± 0.00.065 ± 0.0070.014 ± 0.006
  • a WT, wild type.

  • b Data are expressed in μg/ml.