TABLE 4.

Summary of anti-E protein MAb characteristics indicateda

Binding groupDomainNo. (%) with characteristic indicateda
WNV binding ELISA/IPCF 50% lysis <10 μg/mlNeutralization VNA66 <50 μg/mlAffinity 50% binding <50 ng/mlIn vivo protection PD100 15 mg/kg
ANA156 (40)4 (27)4 (27)1 (7)
BII242 (8)3 (13)00
CNA80000
DIII41 (25)2 (50)1 (25)1 (25)
Total519952
  • a IP, immunoprecipitation; VNA66, antibody concentration yeilding 66% neutralization; PD100, antibody concentration giving 100% protection; NA, not applicable.