TABLE 1.

Effects of HLA-B58s alleles on HIV-1 VL, stratified according to heterosexual HIV-1 transmission categories in Zambiansa

HLA-B58s alleleSeroprevalent subjectsb (n = 276)Seroconvertersc (n = 147)Combined groups (n = 423)
No.MeanΔVLdPNo.MeanΔVLPNo.MeanΔVLP
B58s854.64−0.160.14424.47−0.080.591274.58−0.120.18
B*5801274.49−0.280.06134.56+0.040.86404.52−0.160.23
B*5802185.17+0.460.001144.74+0.240.28324.97+0.330.02
B*5703354.5−0.280.07113.98−0.590.01464.36−0.340.01
B*1516-*1517104.66−0.090.694e144.77+0.120.53
  • a All estimates are from the univariate GEE models.

  • b Seroprevalent subjects, seropositive index partners who were HIV-1 positive at the time of study entry.

  • c Seroconverters, partners of discordant couples who seroconverted during follow-up.

  • d ΔVL values correspond to beta coefficients from the GEE models.

  • e —, not reported due to instability of estimates.