TABLE 2.

Vaccine-induced cellular immune responses do not affect the number of low-dose intrarectal challenges required for infection with SIVmac239a

Vaccinated or control animalNo. of challenges
Vaccinees
    r000143
    r000446
    r000607
    r010086
    r961334
    r971112
    r971137
    r010804
    Avg4.88
    Geometric mean4.50
Controls
    r980597
    r990342
    r990843
    r000418
    r000453
    r000213
    r010345
    r980506
    Avg4.63
    Geometric mean4.17
  • a Animals were challenged intrarectally with 300 TCID50 of SIVmac239. One week later, plasma was analyzed for viral concentration, and the animal was rechallenged while awaiting the results of the viral concentration determination. The date of infection was considered to be 7 days prior to the first positive viral concentration, and the number of challenges was considered to be how many had occurred, including the one on this date.