TABLE 5.

CD4+ (with more than two subjects responding) and CD8+ HIV-1-specific T-cell responses (three out of five subjects mapped) induced in healthy subjects by vaccination

HIVA peptidePosition of immunogenaProteinSequenceCD4 dependentNo. of vaccinees respondingHLA
622-36p24AWVKVIEEKAFSPEVb+2Uc
1349-64p24PQDLNMMLNIVGGHQA+2U
35138-152p24LNKIVRMYSPVSILDb+2U
42166-180p24DRFFKTLRAEQATQEb+3U
61242-256p17GGKLDAWEKIRLRPG+2U
68270-284p17SRELERFALNPSLLEb+4U
69274-289p17ERFALNPSLLETAEGb+4U
76302-316p17TSEELKSLFVTVATLb+2U
77306-320p17LKSLFNTVATLYCVHb+2U
102430-440gp120TVYYGVPVWK3A*0301
  • a Described in reference 26.

  • b Peptide contains previously described promiscuously binding, immunodominant CD4 T-cell epitopes in HIV-1-infected patients (36).

  • c U, HLA restriction of peptide-specific response in vaccinee not defined in this study.