TABLE 5.

List of SIV mutants

Group and abbreviationaNameAmino acid change(s) in GagMacaque(s) in which selected
P
    P1SIVmac239Gag216SL216SV5 and V3
Q
    Q1SIVmac239Gag216S244E373TL216S, D244E, A373TV5
    Q2SIVmac239Gag216S244E375AL216S, D244E, V375AV3
    Q3SIVmac239Gag216S244E376SL216S, D244E, P376SV3
R
    R1SIVmac239Gag216S244E247L312V373TL216S, D244E, I247L, A312V, A373TV5
    R2SIVmac239Gag172S216S244E375AL216S, D244E, V375A, P172SV3
    R3SIVmac239Gag145A216S244E376SL216S, D244E, P376S, V145AV3
  • a Group P, Gag206-216-CTL-escape mutant rapidly selected in 5 weeks; group Q, Gag206-216-, Gag241-249-, and Gag373-380-CTL escape mutants; group R, mutants selected in the reemerged viruses.