TABLE 2.

Convergent PNG changes in gp120 at 32 wpia

Sample(N)bPrevalence (%) of indicated PNG
V1V2C2C3V4V5
136139139C141186188234276362386397460462/3
Inoculumc8100100880100010001000381000
K971078100100100257525750100001000
K980999100100100010001000100001000
L97191910010033010001000100001000
J97168910010056089010001000331000
A9806991001008956330100010067221000
T980989100100785544561003378560440
J97156710010071430100100100100100100086
K9724691001001007801001001008910010000
L98152801008813010002510001002575
T98108101001008070010010010040100300100
J980716100336783100010010010017100067
  • a Percent prevalence of each PNG within the quasispecies. Sites that differ significantly from the inoculum are shown in bold (Fisher's exact P value, <0.05).

  • b Ten proviral clones were sequenced from each animal. Duplicate or missense sequences were removed from analysis. N, number of unique clones incorporated for analysis from each animal.

  • c Proviral clones from the PBMCs used to grow the viral stock of SHIV-89.6P were analyzed as a measure of heterogeneity in the inoculum.