TABLE 2.

Reactions of MAbs with escape mutants of A/Mallard/Pennsylvania/10218/84 (H5N2) virus in HI assay

Escape mutantHA amino acid changeaReactivity with MAbb:
H3 numberingH5 numberingVN04-2VN04-9VN04-10VN04-13VN04-15VN04-16777/1
m46(7)N129DN124D<000000
m46(8)K157MK153M0000−200
m55(2)K156NK152M0<<00<−4
m58(1)D131ND126N0−2<0<<−1
m24B9R144GR140G0000<00
m46(7)-55N129D, K156TN124D, K152T<<00−2<0
m46(7)-55-24B9N129M, K156T, P140LN124D, K152T, P136L<<−2<<<−2
m55(2)-24B9K156N, N142KK152T, N138K0<<0<<<
m58(1)-24B9D131N, S145PD126N, S141P0−2<<<<<
  • a See Table 1, footnote a.

  • b Designations are the same as in Table 1. Values are the differences in log2 units between the HI titers of MAbs in the reactions with the wild-type A/Mallard/Pennsylvania/10218/84 (H5N2) virus and with its escape mutants.