TABLE 2.

Average distribution of mutations in cDNAs as a function of drug treatment

TreatmentNo. of analyzed cDNAs% of cDNAsa with:
No mutationsOne mutationTwo mutationsThree mutationsFour mutations
No treatment46085.712.41.50.40.0
RBV
    41 μM36074.720.84.40.00.0
    61 μM18067.827.23.91.10.0
    82 μM27666.727.54.31.10.4
    123 μM17065.324.19.41.20.0
    164 μM34857.529.310.61.70.9
    246 μM16256.234.64.94.30.0
MPA, 15.6 μM17677.818.83.40.00.0
RBV + MPAb18562.726.58.62.20.0
TIA, 154 μM9081.117.81.10.00.0
SEL, 130 μM9381.716.11.11.20.0
  • a Values represent averages from up to four independent experiments; each experiment contained a minimum of 90 independent cDNAs.

  • b Cotreatment of 41 μM RBV with 3.1 μM MPA.