TABLE 2.

Pentamers used to screen responses for HCV and CMV, including sequence of epitope, restricting allele, median response and range, and number of patients stained for PD-1 on pentamer-positive CTLs

RestrictionHLA restrictionProteinAmino acidsEpitope sequenceMedian response (% CD8+ T cells)aNo. of patients PD1 stained
A1A1NS3-5H1436-1444ATDALMTGY0.47 (0.13-7.30)9
A2A2Core B132-140DLMGYIPAV0.26 (0.10-5.91)14
A2A2NS3-1P1073-1081CINGVCWTV0.55 (0.21-10.58)16
A2A2NS3-5H1406-1415KLVALGINAV0.36 (0.10-5.95)16
A2A2NS5-A11987-1995VLSDFKTWL0.55 (0.21-5.96)14
A2A2NS5-B22594-2602ALYDVVTKL0.28 (0.11-0.88)13
A3A3NS5-B22588-2596RVCEKMALY0.50 (0.16-1.15)8
B7B7Core B111-119DPRRRSRNL0.55 (0.19-0.60)2
B8B8NS3-5H1395-1403HSKKKCDEL0.53 (0.22-0.94)3
A2A2CMVpp65495-503NLVPMVATV0.43 (0.07-15.08)24
  • a The range is indicated in parentheses.