TABLE 2.

IFN response following poly(IC:LC) or WNV inoculation of mice

Mouse genotypeTreatmentaSerum IFN concn (U/ml)b
8 h24 h48 h
IRF3−/−Poly(IC:LC)>28,0001,300<10
WNV1113915
WNV1452011
WNV3982121
WNV1432515
BL6Poly(IC:LC)>28,0002,600<10
WNV2043315
WNV2778023
WNV3041915
WNV1517314
  • a Mice were administered 40 μg poly(IC:LC) or 1 × 107 focus-forming units of WNV per animal i.p.

  • b Determined by bioassay.