TABLE 3.

Phenotype of PD-1high and PD-1low CTLs that specifically target HCV in chronic and resolved infection (peripheral blood)a

AntigenChronicResolvedChronic vs resolved
PD-1highPD-1lowPPD-1highPD-1lowPPD-1highPPD-1lowP
CCR788.99 (18.29-100)57.81 (37.93-76.19)0.000292.12 (30.26-100)74.22 (6.67-93.94)0.0176NSNS
CD2792.54 (48.28-100)83.33 (7.84-95.24)0.011996.30 (38.18-100)84.00 (54.00-100)0.0232NSNS
CD2885.00 (37.61-98.41)52.63 (24.18-83.08)0.000886.21 (9.09-97.92)64.95 (9.76-95.24)NSNSNS
CD45RA91.77 (14.78-100)76.67 (58.33-100)0.040686.04 (42.08-100)53.50 (11.76-100)0.0377NSNS
CD5770.59 (16.05-100)37.01 (12.9-99.55)0.032947.62 (13.98-85.19)11.43 (2.61-72.97)0.00040.03940.0015
CD62L68.12 (6.78-88.8)31.25 (12.5-71.43)0.002853.33 (7.69-87.5)18.07 (0-36.59)0.0002NS0.0014
  • a Values (other than P values) are expressed as median percentages of HCV-specific PD-1high or PD-1low cells coexpressing antigen. Ranges are indicated in parentheses. P values were calculated by using a nonparametric Mann-Whitney U test. NS, not significant.