TABLE 4.

Phenotype of HCV-specific CTLs in peripheral and intrahepatic compartments of chronically infected patients

MarkerMedian % pentamer (range)Pb
PeripheralIntrahepatic
PD-1a60.91 (33.76-161.42)90.19 (42.9-178.53)0.0017
CD2874.51 (40.79-94.2)65 (1.16-97.14)NS
CD2792 (22.5-98.02)93.16 (79.51-98.28)NS
CCR775.72 (24.79-96.47)65.88 (8.62-100)NS
CD45RA86.27 (24.66-100)84.54 (13.99-100)NS
CD5752.83 (21.7-99.56)64.38 (10.85-94.12)NS
CD62L50.72 (13.86-76)43.34 (1.92-89.36)NS
CD6939.62 (9.48-100)96.61 (81.56-100)0.0006
CD12733.33 (2.94-90)6.85 (2.76-33)0.0169
CD45RO89.66 (72.9-100)99.46 (88.52-100)0.0027
  • a Values for HCV-specific CTL (PD-1) are indicated as the MFI. All other values are median percent values.

  • b P values were calculated using the nonparametric Mann-Whitney U test.