TABLE 1.

Representative genes regulated by MVA or NYVAC in infected MDDC according to predicted biological function

DescriptionGenBank accession no.GeneFold change in transcription
MVANYVAC
IFN and IFN-induced genes
    IFN-induced protein with tetratricopeptide repeats 4NM_001549IFIT452.453.37
    IFN-induced protein with tetratricopeptide repeats 1NM_001548IFIT147.84.65
    IFN-induced, hepatitis C virus-associated microtubular aggregate protein (44 kDa)NM_006417MTAP4420.952.63
    IRF-2NM_002199IRF26.543.48
    IRF-7NM_004031IRF72.521.3
    IFN-α1NM_024013IFNA12.511.92
    Myxovirus (influenza virus) resistance 1, IFN-inducible protein p78 (mouse)NM_002462MX12.261.44
    IRF-5NM_002200IRF5−2.311.06
    IFN-α-inducible protein 27NM_005532IFI27−2.46−1.62
    IFN-γ-inducible protein 30NM_006332IFI30−2.79−2.79
Interleukins
IL-6 (IFN, beta 2)NM_000600IL64.051
IL-1αNM_000575IL1A−1.432.01
IL-8NM_000584IL8−2.9−1.39
IL-1βNM_000576IL1B−2.251.39
TNF (TNF superfamily, member 2)NM_000594TNF52.216.79
Other cytokines
    GRO2 oncogene (SCYB2), CXCL2NM_002089GRO26.582.22
    Small inducible cytokine A3NM_002983SCYA34.221.12
    Small inducible cytokine A5 (RANTES)NM_002985SCYA54.17−1.17
    Small inducible cytokine A4NM_002984SCYA43.74−1.14
    Colony-stimulating factor 2 (granulocyte-macrophage)NM_000758CSF23.13−1.08
Apoptosis
    Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor αNM_020529NFKBIA9.596.02
    MAIL, NFKBIZNM_031419MAIL12.994.91
    BCL2-associated athanogene 3NM_004281BAG38.421.28
    Calpain 1, (mu/I) large subunitNM_005186CAPN14.11.78
Antiviral immune response
    Melanoma differentiation-associated protein 5NM_022168MDA57.771.67