TABLE 2.

Differential gene expression profiling of MVA-infected versus NYVAC-infected human DCa

DescriptionGenBank accession no.GeneFold change of MVA/NYVAC
IFNs and IFN-induced genes
    IFN-induced protein with tetratricopeptide repeats 4NM_001549IFIT411.45
    IFN-induced protein with tetratricopeptide repeats 1NM_001548IFIT17.38
    IFN-induced, hepatitis C virus-associated microtubular aggregate protein (44 kDa)NM_006417MTAP445.52
    Guanylate binding protein 5NM_052942GBP55.37
    IFN-β1, fibroblastNM_002176IFNB15.06
    IFN-stimulated protein, 15 kDaNM_005101ISG152.56
    IFN-stimulated gene (20 kDa)BC016341ISG202.51
    IRF-7NM_004031IRF72.31
    IFN-α1NM_024013IFNA11.18
Interleukins
    IL-12β (NK cell-stimulatory factor 2)NM_002187IL12B5.44
    IL-6 (IFN-β2)NM_000600IL64.05
    IL-1αNM_000575IL1A−2.42
    IL-1βNM_000576IL1B−3.14
TNF and related genes
    TNF (TNF superfamily, member 2)NM_000594TNF10.38
    TNF receptor-associated factor 6NM_004620TRAF61.7
    Tumor necrosis factor receptor superfamily, member 10bAF016266TNFRSF10B−1.07
Other cytokines
    Small inducible cytokine A4NM_002984SCYA45.61
    Small inducible cytokine A5 (RANTES)NM_002985SCYA53.06
    GRO2 oncogene (SCYB2), CXCL2NM_002089GRO22.78
    Small inducible cytokine subfamily B member 10, CXCL10, IP-10NM_001565SCYB102.35
    Colony-stimulating factor 2 (granulocyte-macrophage)NM_000758CSF21.94
Apoptosis
    BCL2-associated athanogene 3NM_004281BAG34.55
    MAIL, NFKBIZNM_031419MAIL2.85
    Calpain 1 (mu/I) large subunitNM_005186CAPN11.72
Antiviral immune response
RNA helicaseNM_014314RIG-I5.72
Melanoma differentiation-associated protein 5NM_022168MDA55.05
OASLNM_003733OASL4.53
  • a Shown is a comparison of gene expression profiling between MVA- and NYVAC-infected MDDC. Representative human genes specifically regulated by each vector according to predicted biological function are shown.