TABLE 2.

Detection of CD4i antibodies in two patients prior to and after HIV-1 infectiona

Patient no.Date of blood drawHIV-1 enzyme-linked immunosorbent assay resultPooled RNA PCR resultTime (wk) postinfectionViral load (copies/ml)CD4 T-cell count (cells/μl)Autologous neutralizationbNeutralization of 7312Ab
Without sCD4With sCD4Without sCD4With sCD4
002-10-000828 September 2004NegativeNegative−30NA756ND2020
6 January 2005NegativeNegative−16NANDND2020
3 March 2005NegativeNegative−8NANDND2020
11 May 2005PositiveND2207,000ND202020393
17 May 2005Positive3373,000360202020823
6 July 200510368,0004672020521
7 September 20051973,10032910820263
19 October 20052598,4003439020631
11 January 20063727,60022717620392
23 May 20065639,30033261920154
002-10-020621 April 2005NegativeNegative−4NA1,643ND2020
15 June 2005PositiveND4196,000ND2020202,429
12 July 20058368,000365202020687
30 August 200515113,00029214520145
20 October 200522127,000ND90620170
3 January 200633138,0003251,57720263
21 February 200640252,0002901,291201,619
14 June 200656210,0002972,425202,204
  • a Dates shown in bold are the times of enrollment sample collection. NA, not applicable; ND, not done.

  • b Reciprocal serum dilution that gives 50% neutralization.