TABLE 1.

Summary of clinical and pathological outcomes of study animals

Category and macaqueVirusSurvival time (wk)Major pathological findings
RP
    H147E66014SIVE and pneumonia with MNGC, severe enteritis (protozoal), MNGC in GI tract and prostate
    H168E66022SIVE and pneumonia with MNGC, severe enteritis, MNGC in lymph nodes
    H538E6609SIVE and pneumonia with MNGC, severe enteritis, MNGC in ovary and fallopian tube
    H567E66010SIVE and mild pneumonia with MNGC, severe enteritis, MNGC in lymph nodes and GI tract
    H426E66020SIVE and pneumonia with MNGC, severe enteritis, MNGC in GI tract and eye
    18655E66016SIVE and pneumonia with MNGC, severe enterocolitis, MNGC in thymus, lymph nodes, spleen, GI tract, kidney, and testis
    H445E543-315SIVE and pneumonia with MNGC, severe enteritis
    CK2FE543-331Mild diffuse SIVE, pneumonia with MNGC, severe enteritis
    CK2KE543-315SIVE and pneumonia, severe lymphoid depletion with MNGC, moderate-to-severe enteritis
CP
    H119E66051Disseminated M. avium enteritis and lymphadenitis, lymphoid hyperplasia and involution lymphoma (mesenteric lymph node), focal SIVE
    H120E66054M. avium enteritis, lymphadenitis, lymphoid hyperplasia and involution
    H133E66058P. carinii pneumonia, enteritis, lymphoid depletion
    H187E66054Pyogranulomatous lymphadenitis, cytomegalovirus orchitis, lymphoid depletion
    H454E66072Multicentric lymphoma (heart, adrenals, urinary bladder, ovaries, eye)
    H063E543-3164M. avium enteritis and lymphadenitis, lymphoid depletion
    H460E543-3100Cryptosporidial enteritis, cholecystitis, cholangiohepatitis, lymphoid depletion
    XGEE543-377Suppurative pneumonia with pulmonary thrombosis, lymphoid depletion, enteritis with amyloidosis
    H679E543-360Abscessation of kidney, secondary peritonitis (Staphylococcus aureus), lymphoid depletion