TABLE 1.

Differential expression values determined from gene expression in IL, MLN, and PP lymphocyte populations isolated from naive, LT(R192G)-immunized, and VP6/LT(R192G)-immunized mice at specific time points after EDIM challengea

GroupCell typeGeneDE value at:
12 h1 day2 days4 days6 days8 days
NaiveIL
MLNIFN-α12.2
IFN-α112.5
IFN-α42.7
IFN-α/β2.9
LtB2.02.5
CD40L2.02.9
CD30L2.6
PPIFN-α12.83.9
IFN-α112.43.9
IFN-α43.75.5
IFN-α/β2.34.3
LtB2.45.0
LT(R192G) immunizedILIFN-γ4.2
TRAIL3.3
MLN
PP
VP6/LT(R192G) immunizedILHGF5.9
IFN-α112.2
IFN-α/β3.7
IFN-γ2.97.33.5
IL-173.27.13.3
MLN
PPIL-172.12.9
IL-1β3.6
LtB2.6
  • a DE values were determined by subtracting the corresponding (prechallenge) time zero intensity from the intensity of each subsequent time point (12 h and 1, 2, 4, 6, and 8 days after EDIM challenge). A DE value of ≥2 represents a significant upregulation of expression. Only DE values that met this criteria are shown.