TABLE 1.

Baseline participant characteristics by response group

FeatureValue for patients with:P
Marked responseIntermediate responsePoor response
No.
    Total271725
    AA13 (48%)9 (53%)11 (44%)0.85a
    Male17 (63%)14 (82%)19 (76%)0.33a
Body wt (kg)
    Mean (SD)84.7 (22.5)92.1 (23.4)93.1 (14.6)0.28b
    Median (25th, 75th)79.8 (70.8, 97.1)94.3 (81.2, 99.8)93.9 (79.8, 104.3)
HCV RNA level (log10 IU/ml)
    Mean (SD)6.0 (0.8)6.5 (0.6)6.4 (0.5)
    Median (25th, 75th)5.7 (5.3, 6.8)6.7 (6.2, 6.9)6.4 (6.2, 6.6)0.11c
ALT (mg/dl)
    Mean (SD)101.7 (94.1)69.5 (28.7)129.8 (106.3)
    Median (25th, 75th)68.0 (42.0, 123.0)65 (52.0, 81.0)83.0 (58.0, 164.0)0.13c
Liver histology
    Ishak necroinflammatory score (0-18)
        Mean (SD)8.2 (2.6)7.2 (2.4)7.8 (3.3)
        Median (25th, 75th)8 (6, 9)8 (6, 9)7 (5, 9)0.48c
    Ishak fibrosis score (0-6)
        Mean (SD)2.1 (1.0)1.7 (1.3)2.4 (1.4)
        Median (25th, 75th)2 (1, 3)1 (1, 2)2 (2, 3)0.08c
  • a Chi-square test.

  • b Analysis of variance.

  • c Kruskal-Wallis test.