TABLE 5.

Changes on day 1 for CA and AA and the combined groupa

Function/descriptionSymbolFold change for:P
AllCAAA
Antiviral response
    Interferon-stimulated gene 20 kDaISG202.942.713.190.15
    2′5′-Oligoadenylate synthetase 1, 40/46 kDaOAS15.775.296.260.32
    2′5′-Oligoadenylate synthetase 2, 69/71kDaOAS24.374.164.610.38
    2′5′-Oligoadenylate synthetase-likeOASL6.686.197.150.28
    Radical S-adenosyl methionine domain containing 2RSAD215.6614.7716.560.60
Apoptosis
    XIAP associated factor-1HSXIAPAF13.403.173.610.50
    TRAILTNFSF104.454.054.880.25
Cell proliferation
    Lysosomal-associated membrane protein 3LAMP39.178.919.420.77
Chemokines
    Chemokine (C-C motif) ligand 2CCL246.8839.6853.270.36
    Chemokine (C-C motif) receptor 1CCR13.583.463.690.68
    Chemokine (C-C motif) ligand 8CCL89.587.8510.910.29
    Chemokine (C-X-C motif) ligand 11CXCL115.625.176.190.48
    Chemokine (C-X-C motif) ligand 10CXCL1021.8119.5124.340.25
Complement pathway
    Complement component 3a receptor 1C3AR13.022.803.310.21
    Serine (or cysteine) proteinase inhibitorSERPING110.649.5111.940.28
Endonuclease
    Liver RNase (neurotoxin)RNAse22.542.492.600.73
Helicase
    Hypothetical protein FLJ20035FLJ200353.924.103.730.42
    Interferon induced with helicase C domain 1IFIH13.913.694.090.64
Immune response
    Alpha interferon-inducible protein (clone IFI-15K)G1P28.787.809.890.22
    Alpha interferon-inducible protein (clone IFI-6-16)G1P33.753.424.110.31
    Alpha interferon-inducible protein 27IFI2725.9821.9129.710.39
    Interferon-induced protein 35IFI353.963.634.340.31
    Interferon-induced protein 44IFI445.325.625.020.66
    Interferon-induced protein 44IFI44L7.387.257.520.49
    Interferon-induced protein with tetratricopeptide repeats 1IFIT112.6813.1012.300.88
    Interferon-induced protein with tetratricopeptide repeats 3IFIT39.409.629.190.78
    Interferon-induced protein with tetratricopeptide repeats 5IFIT52.982.893.080.84
    Interferon induced transmembrane protein 1 (9-27)IFITM11.821.771.860.55
    Interferon induced transmembrane protein 3 (1-8U)IFITM32.492.352.630.49
    IL-1 receptor antagonistIL1RN4.764.195.470.31
    Myxovirus (influenza virus) resistance 1MX15.295.475.120.11
    Myxovirus (influenza virus) resistance 2MX23.923.674.190.65
Inflammatory response
    HeparanaseHPSE3.653.224.190.03
    SialoadhesinSN28.3128.6628.020.96
JAK-STAT cascade
    N-myc (and STAT) interactorNMI2.602.472.760.35
    Signal transducer and activator of transcription 1 (91 kDa)STAT12.172.112.240.54
Phospholipid scrambling
    Phospholipid scramblase 1PLSCR14.003.754.290.31
RNA editing
    Apolipoprotein B mRNA editing enzymeAPOBEC3A4.884.265.700.06
Signal transduction
    Membrane-spanning 4 domains, subfamily A, member 4MS4A4A5.514.686.400.07
AllCAAA
Toll pathway
    Toll-like receptor 7TLR75.665.375.980.51
Transcription factor/repressor
    CD38 antigen (p45)CD382.462.292.640.16
    Homeobox (expressed in embryonic stem cells) 1HESX122.4119.6325.530.24
    Gamma interferon-inducible protein 16IFI162.072.042.100.67
    Interferon regulatory factor 7IRF73.843.494.220.13
    Lectin, galactoside-binding, soluble, 9 (galectin 9)LGALS92.562.492.630.74
    Lymphocyte antigen 6 complex, locus ELY6E3.953.794.130.73
    Nuclear antigen Sp100SP1001.921.961.880.69
    SP110 nuclear body proteinSP1101.711.751.670.65
    T-box 3 (ulnar mammary syndrome)TBX35.935.905.960.94
Ubiquitin pathway
    Hect domain and RLD 5HERC57.307.137.470.75
    Hect domain and RLD 6HERC65.014.825.240.43
    Promyelocytic leukemiaPML3.313.183.440.48
    Ubiquitin-conjugating enzyme E2L 6UBE2L62.692.512.900.07
    Ubiquitin-specific protease 18USP189.628.3711.100.12
Unknown function
    28-kDa interferon-responsive proteinIFRG284.313.695.010.01
  • a Changes (n-fold) were defined as +averageday 1/averageday 0, if averageday 1 > averageday 0, or as −averageday 0/averageday 1, if averageday 1 < averageday 0. The standard error of a change (n = fold) was estimated by the delta method. A two-sample Z test was constructed to compare changes (n = fold) between CA and AA according to the equation Z = FCCA − FCAA/(std.FCCA2 + std.FCAA2)1/2, where Z is approximately standard normal, FCCA and FCAA are the changes (n-fold) for CA and AA, respectively, and std.FCCA and std.FCAA are corresponding standard errors.