TABLE 2.

Protective role of immune seraa

GroupClinical sign(s)Protection (%)
Naïve + PR8Sick, loss of wt, dead0
Normal sera + PR8Sick, loss of wt, dead0
Immune sera + PR8Healthy100
Naïve + WSNSick, loss of wt, dead0
Normal sera + WSNSick, loss of wt, dead0
Immune sera + WSNHealthy100
  • a Naïve mice were intranasally administered pooled sera from mice immunized with influenza HA VLPs (immune sera) or naïve mouse serum (normal sera). Then, mice were challenge infected with a lethal dose (10× LD50) of live PR8 or WSN after 2 h. The mouse survival and body weight changes were recorded daily.