TABLE 1.

Genomic analyses of adenovirusesa

Receptor usageSerotypeSubgroupAmt of CpG (count/ genome)Amt of rrCpGyy (count/genome)Frequency of rrCGyy (per 1,000)
CD46Ad7B1,7011002.82
CD46Ad11B1,6391173.36
CD46Ad35B1,6381173.36
CARAd12A1,5001363.99
CARAd1C2,4361534.25
CARAd2C2,4281544.29
CARAd5C2,4141514.20
CARAd17D2,4101424.05
CARAd4E2,5391634.53
CARAdFF1,9891554.53
  • a The overall numbers of CpG islands and rrCpGyy motifs were determined for each serotype by sequential searching for the string in the five different frameshifts of each sequence. The relative frequency of the number of motifs was computed by dividing the observed number of motifs by the corrected genome size (sum of the number of linear 6-mer strings of nucleotides). Note that the range of counts of rrCpGyy for serotypes that use CD46 (110 to 117) does not overlap the range of counts for CAR-utilizing Ads (136 to 163).