TABLE 2.

Protection induced by Ebola VRP vaccinationa

VRP immunogenDose (no. of IU)No. of survivors/total no. of mice tested
BALB/cC57BL/6
GP2.0 × 1069/1010/10
NP2.0 × 10610/1015/16
VP242.0 × 10615/150/40
VP302.0 × 10625/2525/25
VP352.0 × 10638/4040/40
VP402.0 × 10615/1516/20
Lassa N2.0 × 1060/200/20
  • a Protection induced by VRPs expressing Ebola virus GP, NP, and VP proteins. Mice were vaccinated three times with 2.0 × 106 IU of VRPs as determined by the flow cytometry analysis of titer and then challenged with 1,000 PFU of mouse-adapted Ebola virus 28 days after the last vaccination. Mice were observed for 28 days after challenge.