TABLE 1.

HIV-1 mutations

Subject and mutationaProteinSiteSequencePolymorphismHLA associationORbP
Mutations associated with HLA alleles expressed by current host
    AC-38
        1Gag28RLRPGGKKKK→QA*03018.44<0.0001
        2Gag79GSEELRSLYY→FA*01012.710.0048
        3Gag147ISPRTLNAWI→LC*06026.410.0001
        5cGag310YKTLRAEQATQEVKNWMTET→SB*070210.160.0034
        37Rev30LLYQSDPPPSPEGTRQARRS→NC*07022.630.0182
        48Nef114RQDILDLWVYV→IC*07015.880.0001
        49Nef116HTQGYFPDWQH→NB*57015.30<0.0001
    AC-04
        2Gag357ACQGVGGPGHKG→SA*11012.990.0153
        9Tat32CCFHCQVCF→XC*120323.150.0043
A*02078.920.0486
    AC-16
        10Pol726QEEHEKYHSNWE→AB*440217.76<0.0001
        10Pol726QEEHEKYHSNWE→AB*44035.44<0.0018
        13aVif183WNKPQKTKGYRGSHTMSGHY→HB*44022.09<0.0001
Transmitted HLA-associated mutations reverting to consensus
    AC-38
        5Gag310YKTLRAEQATQEVKNWMTET→SA*30010<0.0001
B*42010<0.0001
B*15030.070.0493
        6Gag403NCGKEGHIAKNCRAPRKKGK→RA*31010.040.0028
A*33030.050.0066
B*18010.280.0317
B*53010.080.0328
        29bTat67APQDsQTHQAsiSKQPTSQA→VC*15020<0.0001
        32Vpu44RQRKIDRLIERIRERAEDSE→DC*01020.250.0276
        33Vpu65ESDGDQEEL--LVEMGHLA_→SC*02020.210.0413
        51Nef152FKLVPVDPDEVEEANEGENE→KC*05010.180.0213
    AC-59
        2Vpr48LHGLGQQIYGTYGDTWEGVG→EB*46010.050.0008
A*30010.040.0102
B*49010.130.0107
B*15030.130.0311
    AC-16
        14Tat71SQTHQVPLPEQPNSQPRGDE→KA*01010.190.0230
C*03040.210.0379
        21Nef71EDEEVGFPVKPQVPLRPMTK→RC*07020.070.0000
B*40020.130.0491
  • a Mutation numbers correspond to Fig. 2A and to Fig. S1 and Table S1 in the supplemental material.

  • b OR, odds ratio.

  • c Associations observed for both forward and reverse mutations.