TABLE 6.

Sensitivity of Env clones to neutralization by V3-specific MAbs

Env cloneaPanel designationaID50 in TZM-bl cells (μg/ml)b
21822442219122192456447D
SF162.LSNone2<0.04<0.04<0.040.040.04
6101.10SVPB1>25>25>25>25>25>25
5768.4SVPB2>25>25>25>25>25>25
3988.25SVPB3>25>25>25>25>25>25
7165.18SVPB4>250.040.9025>25>25
6535.3*SVPB5*>250.040.401.550.1
QH0692.42*SVPB6*1>25>25>25>25>25
QH0515.1SVPB7>25>25>25>25>25>25
SC422661.8*SVPB8*>25>25>25>25>25>25
SS1196.1SVPB9<0.040.040.400.10.1<0.04
BG1168.1SVPB10>25>25>25>25>25>25
PVO.4*SVPB11*>25>25>25>25>25>25
TRO.11*SVPB12*>25>25>25>25>25>25
AC10.0.29*SVPB13*>25>25>25>25>25>25
RHPA4259.7*SVPB14*>25>2525>25>25>25
THRO4156.18*SVPB15*>25>25>25>25>25>25
REJO4541.67*SVPB16*>25>25201>25>25
TRJO4551.58*SVPB17*>25>25>25>25>25>25
WITO4160.33*SVPB18*>25>25>25>25>25>25
CAAN5342.A2*SVPB19*>25>25>25>25>25>25
  • a Clones selected as standard reference strains are marked with an asterisk.

  • b Values are the concentration at which RLU were reduced 50% compared to those in virus control wells.