TABLE 1.

CD4+ T-cell count and plasma virus levels following SHIV-89.6P inoculation

ParameterIndian rhesus (n = 20)Chinese rhesus (n = 8)Cynomolgus (n = 8)Pa
CD4+ T cells (median no. of cells/μl ± range)
    Baseline1,369 (1,308-1,713)1,124 (495-1,878)831 (585-1,420)0.069
    Days 35-7710 (2-888)124 (6-406)*260 (85-376)*0.002
    Days 84-3005 (0-955)343 (10-933)*360 (158-469)*<0.001
Plasma virus (median log10 copies/ml ± range)
    Peak7.98 (6.38-8.69)8.07 (7.84-8.50)7.23 (6.65-7.43)*<0.001
    Days 35-775.46 (3.88-6.51)4.41 (2.93-5.74)*3.11 (2.70-4.09)*<0.001
    Days 84-3005.96 (2.70-7.56)4.18 (2.70-6.70)*2.70 (2.70-3.18)*<0.001
  • a Kruskal-Wallis test comparing medians between groups. *, significantly different from Indian rhesus, Wilcoxon test, P < 0.05 (adjusted for two comparisons).