Protection from virus replication in the lower respiratory tracts of mice following passive transfer of anti-SARS MAb 80R

Passive-transfer MAba (500 μg/ml)Virus replication in lungs of challenged micebP valuec
No. infected/no. testedMean (± SE) virus titerd
Undiluted control MAb4/45.7 ± 0.1
80R undiluted0/4≤1.5 ± 0e0.00000001
80R diluted 1:53/42.0 ± 0.20.0000035
80R diluted 1:254/44.6 ± 0.260.007
  • a The indicated dilutions of MAb in 500 μl were administered to recipient mice by intraperitoneal injection.

  • b Mice were challenged with 104 TCID50 of SARS-CoV intranasally.

  • c P values comparing titers with those seen in mice that received the control antibody in a two-tailed Student t test.

  • d Virus titers are expressed as log10 TCID50/g of tissue.

  • e Virus not detected; the lower limit of detection of infectious virus in a 10% (wt/vol) suspension of lung homogenate was 1.5 log10 TCID50/g.