TABLE 2.

Anti-norovirus salivary IgA response elicited by SMV challenge

ParameterValue [median (range)]
InfectedaUninfected
Anti-SHV IgAb
    Prechallengec0.12 (0.04-1.21)0.24 (0.07-0.73)
    Postchallenged0.85 (0.33-1.84)0.22 (0.16-1.2)
    Increasee5.6g (1.5-36.8)1.4 (0.64-2.0)
    Volunteers converted (%)f670
Anti-HV IgAh
    Prechallenge0.06 (0.03-0.32)0.15
    Postchallenge0.19 (0.13-0.28)0.15
    Increase2.2 (0.8-9.3)1.0
    Volunteers converted (%)200
Anti-NV IgAh
    Prechallenge0.03 (0.008-0.06)0.06
    Postchallenge0.07 (0.005-0.12)0.07
    Increase2.3 (0.63-3.0)1.2
    Volunteers converted (%)00
  • a Viral RNA detected in stool.

  • b (Microgram of VLP-reactive salivary IgA per milliliter/microgram of total salivary IgA per milliliter) × 100. n = 6.

  • c Day zero.

  • d Day 14 or 21.

  • e Median of individual increases (n-fold) above prechallenge titer.

  • f Percentage of volunteers with ≥4-fold increase over the prechallenge titer.

  • g P ≤ 0.05.

  • h n = 5 (infected); n = 1 (uninfected).