TABLE 2.

Genes of cluster 1, representing probe sets with increased signal intensities in MVA-ΔE3L infected HeLa cells compared to MVA-infected cell results at 2.5 or 5 h postinfection calculated as severalfold change factors derived from a comparison to corresponding mock-expression values

Gene group and designationProbe setaAccession no.DescriptionSeveralfold change at:
2.5 h p.i.b5 h p.i.
MVAΔE3LcMVAΔE3L
Signaling
    AKAP12210517_s_atNM_005100A kinase (PRKA) anchor protein (gravin) 121.080.720.471.82
    DUSP1201041_s_atNM_004417DUSP1 (MKP-1)1.041.451.102.52
    DUSP1201044_x_atNM_004417DUSP1 (MKP-1)0.831.192.5212.13
    DUSP5209457_atNM_004419DUSP5 (HVH3)1.311.101.153.10
    GADD45β209305_s_atNM_015675Gadd4β1.211.250.811.87
    GADD45β207574_s_atNM_015675Gadd45β1.481.551.384.49
    GADD45β209304_x_atNM_015675Gadd45β1.301.732.147.13
Transcription
    ATF3202672_s_atNM_001674ATF31.831.541.007.29
    ID1208937_s_atNM_002165Inhibitor of DNA binding 1, helix-loop-helix protein1.111.140.782.46
    SOX9202935_s_atNM_000346SRY (sex determining region Y)-box 90.800.690.692.14
    TAF7201023_atNM_005642TATA box binding protein-associated factor1.221.130.461.26
    JUNB201473_atNM_002229jun B proto-oncogene1.741.900.852.05
    NR4A1202340_x_atNM_002135Nuclear receptor subfamily 4, group A, member 11.711.900.853.10
    NR4A2204621_s_atNM_006186Nuclear receptor subfamily 4, group A, member 21.771.952.838.77
    SNA12213139_atNM_003068Snail homolog 2 (Drosophila)0.790.830.563.65
    TIEG202393_s_atNM_005655TGFB-inducible early-growth response1.141.080.911.91
    JUN201464_x_atNM_002228v-jun sarcoma virus 17 oncogene homolog2.392.300.835.79
    MAFG204970_s_atNM_002359v-maf homolog G (avian)1.211.010.811.78
    SNAPC1205443_atNM_003082Small nuclear RNA activating complex1.601.181.182.30
Immune response
    CXCL2209774_x_atNM_002089Chemokine (C-X-C motif) ligand 21.020.910.762.70
    F3204363_atNM_001993Coagulation factor III0.981.332.354.49
    IL6205207_atNM_000600IL-6 (IFN, beta 2)1.641.661.079.19
mRNA splicing
    SFRS10210180_s_atNM_004593Splicing factor, arginine/serine-rich 101.040.940.541.48
    SFRS6206108_s_atNM_006275Splicing factor, arginine/serine-rich 61.471.700.351.74
Histones
    H1F2209398_atNM_005319H1 histone family, member 20.984.120.452.64
    H2BFA210387_atNM_003518H2B histone family, member A1.460.660.623.40
    H4FB208076_atNM_003539H4 histone family, member B2.493.361.182.83
    H4FG205967_atNM_003542H4 histone family, member G1.573.240.852.30
Miscellaneous
    MCL1200796_s_atNM_021960Myeloid cell leukemia sequence 1 (BCL2-related)1.391.240.792.89
    IER3201631_s_atNM_003897Immediate-early response 31.551.590.783.25
    IER5218611_atNM_016545Immediate-early response 51.321.230.711.70
    ADM202912_atNM_001124Adrenomedullin0.840.910.561.59
    SE20-4218012_atNM_022117T-cell lymphoma-associated tumor antigen1.281.610.833.10
    CYR61210764_s_atNM_001554Cysteine-rich, angiogenic inducer, 612.122.293.257.64
    EFNB2202669_s_atNM_004093Ephrin-B21.440.980.681.70
    ING3205070_atNM_019071Inhibitor of growth family, member 31.511.380.601.15
    GIP2205483_s_atNM_005101IFN, alpha-inducible protein (clone IF1-15K)1.001.420.714.59
    MIR220319_s_atNM_013262Myosin regulatory light chain interacting protein1.341.260.691.23
    TXNIP201009_s_atNM_006472Thioredoxin interacting protein1.231.291.022.05
    TNFAIP3202644_s_atNM_006290Tumor necrosis factor, alpha-induced protein 30.720.600.691.66
    LOC57018220046_s_atNM_020307Cyclin L ania-6a1.641.831.122.24
    DJ465N24.2.1209007_s_atNM_020317Hypothetical protein dj465N24.2.12.272.810.621.82
    HRY203394_s_atNM_005524Hairy homolog (Drosophila)1.901.991.205.66
210592_s_atSpermidine-spermine N1-acetyltransferase1.791.770.621.70
222303_atESTs1.261.070.601.78
AFFX-r2-Hs28SrRNA-M_at1.201.374.098.19
  • a Probe set designations correspond to GeneChip Human Genome U133A (Affymetrix).

  • b hpi, hours postinfection.

  • c MVA-ΔE3L (ΔE3L).