TABLE 2.

Detection of neutralizing antibodies in serum and SARS-CoV in postmortem tissues

Group (virus isolate)Animal no.Time of euthanasia (dpi)Neutralizing antibody titeraDetection in postmortem tissuesc
LungHeartSpleenLymph nodeKidneyLiver
A (GZ01)63NDb+/+−/−−/++/++/++/+
51320−/−−/+−/+−/ND−/−−/−
142380−/−−/−−/+−/+−/−−/−
43440−/−−/−−/+−/+−/−−/−
33540−/−−/−−/−−/+−/−−/−
B (BJ01)133<10+/++/++/++/++/++/+
71320−/−−/−−/+−/+−/+−/+
112380−/−−/−−/+−/+−/−−/−
103480−/−−/−−/+−/+−/−−/−
83580−/−−/−−/−−/+−/−−/−
  • a All animals were tested prior to inoculation, and none of the animal had neutralizing antibodies to SARS-CoV in their prebleed sera.

  • b ND, not determined.

  • c Virus isolation/RT-PCR results are depicted. +/+ indicates positive for both virus isolation and PCR, whereas −/+ means that particular tissue gave positive PCR signals but virus isolation was negative.