TABLE 1.

Neutralization titers in plasma

Vaccine groupAnimal no.Neutralization titer against HIV-1 isolatea
HxB2BaL89.6SF162JRCSFMuLV-GFP
HxB2/BaL Env1105<5<52515<5
215510<56520<5
380510405<5
4120<5<53510<5
5305<5505<5
690<5<55<5<5
89.6P Env175<59025<5<5
290<545<5<5<5
365<5602015<5
4115<5405<5<5
525<545<5<5<5
680<5802020<5
  • a Values are reciprocal plasma dilutions that produced 50% virus neutralization, based on serial plasma dilutions starting at 1:5. A dose-response curve was fit with a nonlinear function, and the dilutions producing 50% effects were calculated from the curve fit. MuLV is an Env-pseudotyped GFP reporter virus, as described in Materials and Methods.