TABLE 2.

Class-specific residues that distinguish different known and suggested antigenic norovirus strains belonging to different evolutionary classes for partitions P01 to P07 of the phylogenetic tree constructed from a subset (S1 to S56) of sequences of Fig. 1a

Partitions (from Fig. 1)Evolutionary classSequence clusters in classAntigenic norovirus strains in classClass-specific residues and insertions that occur in the different evolutionary classes corresponding to the first few partitions
TotalID
P011S1-S56DSV, SOV, NV, MXV, HV, SMV, LSV
P02, P03, P042GIS1-S10DSV, SOV, NV44A, 70I, 104V, 106N, 163E, 201V, 203A, 204G, 226Q, 329H, 375W, 377S, 397S, 414F, 434P, 460H, 463D, 471G, 485P*, 486N*, 500V, 514K, 519A, 527G*
GIIS12-S56MXV, HV, SMV, LSV44P, 70V, 104A, 106G, 163P, 201T, 203S, 204C, 226S, 329G, 375P, 377G, 397G, 414P, 434D, 460R, 463N, 471F, 500Y, 514A, 519G
P053GIaS1-S10DSV, SOV, NVGI + [83L, 181R, 227K, 306G, 492P]
GIIaS12-S42MXV, HV, SMVGII + [83L, 181R, 227K, 306G, 492P]
GIIbS43-S56LSVGII + [83A, 181K, 227R, 306W, 492D]
P067GIbS1-S3DSVGIa + [46A, 229K, 232S, 236L, 241L]
GIcS4-S6SOVGIb: [199S, 229R, 232T, 236I, 310M]
GIdS7-S9NVGIb: [84S, 197G*, 229R, 232T, 241L,]
GIIcS12-S23MXVGIIa + [46T, 195G*, 199V, 229K, 232T]
GIIdS25-S37HV, SMVGIIa: [65N, 241L, 509Q]
GIIeS39-S42HV, SMVGIIa: [46V, 250V, 509Q]
GIIfS43-S56LSVGIIa: [46A, 250L, 275V, 306W, 310D]
P078GIbS1-S3DSVP06+ 43A, 65Q, 82D, 125I, 133A, 142A, 149I, 156E, 160V, 203C, 223N, 239N, 240T, 246V, 253M, 259H, 288C, 301L, 347*, 356L, 389P, 401E, 422M, 446V, 452T, 504V
GIeS4-S5DSVP06+ 43L, 65Q, 82D, 125I, 133Q, 142A, 149I, 156D, 160V, 203C, 223T, 239K, 240Y, 246I, 253M, 259Q, 288C, 301L, 347P, 356L, 389F, 401E, 422M, 446I, 452I, 504A
GIdS7-S9NVP06+ 43V, 65Q, 82D, 125V, 133G, 142A, 149I, 156D, 160V, 203C, 223T, 239S, 240S, 246A, 253M, 259N, 288A, 301L, 347T, 356L, 389L, 401E, 422M, 446A, 452T, 504V
GIIcS12-S23MXVP06+ 43A, 65G, 82N, 125F, 133P, 142I, 149I, 156E, 160L, 203R, 223T, 239S, 240E, 246F, 253L, 259E, 288C, 301L, 347T, 356L, 389Q, 401H, 422R, 446Y, 452A, 504E
GIIgS25-S32HVP06+ 43A, 65N, 82N, 125F, 133P, 142I, 149I, 156E, 160L, 203R, 223T, 239G, 240E, 246F, 253L, 259E, 288C, 301V, 347T, 356L, 389Q, 401L, 422R, 446Y, 452S, 504D
GIIhS33-S37SMVP06+ 43A, 65N, 82N, 125F, 133P, 142I, 149I, 156E, 160L, 203R, 223T, 239G, 240E, 246F, 253M, 259E, 288C, 301I, 347T, 356L, 389Q, 401L, 422R, 446Y, 452S, 504D
GIIiS39-S41SMVP06+ 43A, 65A, 82D, 125F, 133P, 142L, 149V, 156E, 160L, 203R, 223S, 239S, 240E, 246F, 253M, 259E, 288C, 301L, 347T, 356I, 389Q, 401N, 422R, 446Y, 452A, 504E
GIIfS43-S56LVP06+ 43A, 65G, 82S, 125F, 133P, 142V, 149I, 156E, 160I, 203R, 223T, 239E, 240E, 246F, 253L, 259S, 288C, 301L, 347T, 356L, 389Q, 401R, 422R, 446Y, 452A, 504D
  • a Only seven partitions P01 to P07 are shown because these are sufficient to clearly demonstrate all the relevant ET features discussed in the text. The remaining partitions can be viewed as supplementary data (http:/ncmi.bcm.tmc.edu/∼chin ). Although class-specific residues are shown beginning at residue 1 in Fig. 2, only residues in locations 44 and higher are shown here because of the lack of knowledge of some of the N-terminal residues in the NV crystal structure. All known antigenic strains are resolved in partition P07. All class identification (ID) codes contain three characters: the first two characters are GI for all genogroup 1 classes, and they are GII for all genogroup 2 classes. These class IDs identify individual classes occurring at a given ETC position. All the sequences of these classes are shown in Table 1. The hinge region residues and the P domain residues are boldfaced in contrast to the S domain class-specific residues. Residue numbers correspond to that of NV. *, insertions; P0n+, including all class-specific residues of the previous class denoted by the number n.