TABLE 3.

Surface-forming neighbors of class-specific residues that distinguish the GI noroviruses from the GII strains in partitions P02 to P04

Class-specific residues (NV numbering)SurfaceNeighbors forming the surfacesa
1044A#11042A, 1043V*, 1045T*#, 1046A
1070I21069T, 1071S, 1202V$%, 1074N, 1186L, 1080L, 1113L$, 1152V, 1190L%, 1201V$
1104V, 1106N31036V#, 1037A*#, 1103W, 1105G, 1106N, 1107M, 1108R, 1162L, 1163E, 1164D, 1166R, 1169L*, 1170F, 1213D, 1214F, 1215N, 1217L
1163E41033M*#$, 1034D*, 1036V, 1106N, 1162L, 1164D, 1165V*#, 1180M
1201V$%, 1203A*, 1204G51067E$, 1068F$, 1070I, 1071S, 1112M*$, 1113L$, 1114A*$, 1200F$%, 1202V$, 1203A*$, 1205R*$%, 1512Q
1226Q61225E*#, 1227K*, 1229R, 1449Q*, 1228T
1329H§, 1375W§, 1377S71326C, 1327D, 1328W, 1330I§, 1342Q§, 1343Y, 1344D, 1374S, 1376I, 1378P, 1379P, 1426P§, 1427G§, 1428P§, 2338S, 2339S, 2340Q
1397S*81353V, 1395Y, 1396G, 1398S, 1399I*
1414F91074N, 1412P, 1413G, 1415G*, 1484V, 1512Q
1434P101245R, 1265F, 1389L, 1390W, 1420F, 1421F, 1422M, 1432N*, 1433L, 1435C
1460H, 1463D, 1500V111235N*, 1236L, 1459L, 1461Y, 1462V, 1464P*$%, 1465D$%, 1466T$%, 1467G$%, 1468R*%, 1469N*, 1471G, 1472E, 1499G, 1501F, 1502V$, 1504V
1471G131461Y, 1470L, 1472E, 1516V, 1518T, 1519A
1485P, 1486N141417V, 1483C, 1484V, 1487G, 1488A*, 1490S, 1516V, 1517G, 1518T, 1519A
1514K*$%151484V, 1513L, 1515P*, 1516V
  • a These 4.0 Å sphere neighbors form class-specific surfaces (in boldface) in the NV crystal structure. The C terminus residues are italicized. To identify the different subunits, residues are denoted as xxxxN where xxxx is a four-digit number and N is the single-letter amino acid code of the residue. The first digit of xxxx refers to the subunit number (1, A; 2, B; 3, C) and the remaining three digits are the residue numbers; e.g., residue 1044 refers to 44 of A subunit; residue 2338 refers to residue 338 of B subunit. Superscript asterisk denotes exposed residues. The symbol # denotes residues interacting across the quasi-three fold axis, while the symbols §, $, and % denote residues interacting across the icosahedral twofold, fivefold, and threefold axes respectively.