TABLE 5.

Class-specific residues of the CS-4 surfacesa

Residue no.Residue in GI strain (ID code)Residue in GII strain (ID code)
NV* (A1)Aichi (A2)KY-89 (A3)VA387* (A27)Grimsby* (A26)MXV* (A60)MOH* (A45)VA207* (A37)
326CKKKEL
327DIIVVL
328WQQFFY
330IMMVVV
338STTTNDel
339SRRRRDel
340QAAAADel
342QKKEDDel
343YAAAADel
344DTTKVDel
374STTTTT
376IVVVVVII
378PVVILI
379PIINGY
426P
427GDelDelDelDelDel
428PDelDelDelDelDel
  • a Class-specific residues of the putative receptor-binding surface (patch CS-4 in Table 4 corresponding to surface 7 in Table 3) of NV along with the corresponding ET-aligned residues of GI and GII norovirus strains for partition P06. Strain names and their identification (ID) codes are from Fig. 1. All residues are denoted by their one-letter amino acid codes and they are NV numbered. Blank entries indicate residues that are identical with NV. An asterisk indicates strains for which receptor-binding data are available (15). Del, deletion.