TABLE 3.

Nucleotide substitutions in YFV 3′ UTRs

3′ UTR nucleotide no.Nucleotide in virusLocationa
YF5.2ivSPYF-MNSPYF
10,508GGUYF17D repeat 3, invariant hairpin 1
10,555AGGDimorphic region I, disrupted hairpin 11
10,631UCUConserved region II, invariant hairpin 4
  • a Location of substitutions refers to putative RNA structures as described in references 36 and 41. Sequences for YF5.2iv and SPYF-MN are based on the molecular clones for these viruses (40, 41). Sequences for SPYF are based on the population sequence obtained on viral RNA isolated from brains of ICR mice.