TABLE 4.

Neutralizing activity of the rhesus anti-SIV Fab panol

FabConcn of Fab fragment (μg/ml) reducing infectivity by 50%a
SIV239g45g46g56M5SIV316ΔV1V2
346-4NDND0.06
346-16h1.50.50.20.0030.05
346-19h0.61.30.020.4
346-23hND
346-24h3.40.4
346-25h12.5NDND0.7
347-1h6.90.010.7
347-2h10.4NDNDND
347-5h0.04
347-6h0.9ND
347-10h12.50.01
347-19h33.6ND4.7
347-23h2.00.70.00070.1
B6
  • a The numbers indicate the concentration of Fab fragment required to reduce infectivity of the indicated virus by 50%. −, 50% neutralization was not achieved even at the highest concentration tested. ND, not determined.