TABLE 1.

Neutralization by murine anti-SIV MAbs

MAbEpitopeNeutralization activity for virusa
SIV239g46g56M5SIV251labSIV316ΔV1V2
KK17NH2301010>2,5602 × 1062 × 105
KK68C1
KK65V1 loop102410ND
KK8V1-V21050
KK42V3 loop2015>2,560ND1.5 × 105
KK45V3 loop10160ND2.2 × 104
KK46V3 loop2010>2,5606.5 × 104>1.3 × 106
Senv7.1V4/conf.b602025>2,5606 × 10615
Senv101.1V4/conf.4215>2,560ND
KK5V4/conf.12ND3 × 104
KK9V4/conf.ND>1.3 × 106
KK15gp41ND
KK41gp411645200>2,560>1044.1 × 104
VM18s?c
KK57?640ND6 × 104
Senv50.1?50ND
Senv71.1?10ND
  • a The numbers are the reciprocal of the dilution of ascites fluid required to reduce infectivity of the indicated virus by 50%. -, 50% neutralization was not achieved, even at the lowest dilution (highest concentration) tested; >, the highest dilution (lowest concentration) tested still gave greater than 50% neutralization, and sufficient dilutions were not performed to reach the 50% endpoint. ND, not determined.

  • b conf., conformational.

  • c ?, the precise epitope has not been determined.