TABLE 3.

Immune responses of vaccinated macaques correlated with reduced viral burdensa

Cellular or humoral response by viral burden groupP value at:
Peak prechallengeTime of challengeWk 2 postchallengebWk 4 postchallengeb
Cellular response
    Envelope
        Intermediate versus high0.0570.057
        Low plus intermediate versus high0.024
        Low versus intermediate versus high0.0280.014
    Gag
        Low versus intermediate versus high0.00390.0013
    Paired Gag and envelope
        Low plus intermediate versus high0.051
Humoral response
    Binding Antibody to gp120: Nasal IgG
        Low versus high0.029
        Low plus intermediate versus high0.028
    Paired Nasal IgG plus IgA
        Low versus high0.029
        Low plus intermediate versus high0.032
    Paired vaginal plus nasal IgG
        Low versus high0.029
        Low plus intermediate versus high0.042
    Paired serum, nasal, and vaginal IgG
        Low versus high0.029
        Low plus intermediate versus high0.057
    Neutralizing antibody
        Low versus high0.057
  • a P values <0.05 are considered statistically significant. We also report comparative outcomes approaching statistical significance.

  • b Postchallenge comparisons include both immunized and control non-Mamu-A∗01 macaques.