TABLE 2.

Estimated amounts of MAb H36-4 in respiratory tract after i.n. or i.p. administration of a 50% therapeutic dose

RouteTotal amt inoculated (μg)Total Ab concn in serum on day 1 (μg/ml)Total amt of Ab (ng) in respiratory tract after:
24 h5 days
i.n.2.4<0.01400a21b
i.p40102c16d
  • a (1/3 of inoculum)/2 (one half-life).

  • b 400 ng/20 (4.4 half-lives).

  • c 10 μg × 0.00066 (BALF/serum on day 1) × 0.3 (ml of BALF). A single BAl was performed with 0.3 ml.

  • d 5.8 μg (concn in serum on day 5) × 0.0023 (day 4 to 17 BALF/serum) × 0.3 (ml of BALF) × 4 (increased transudation relative to day 1).